Volume 31, Issue 12
Preparative Organic Chemistry
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ChemInform Abstract: Two Efficient N-Acylation Methods Mediated by Solid-Supported Reagents for Weakly Nucleophilic Heterocyclic Amines.

Kyungjin Kim

Kyungjin Kim

Roche Res. Cent., Hoffmann-La Roche Inc., Nutley, NJ 07110, USA

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Kang Le

Kang Le

Roche Res. Cent., Hoffmann-La Roche Inc., Nutley, NJ 07110, USA

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First published: 09 June 2010

Abstract

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ChemInform Abstract

Amides are prepared by the reaction of weakly nucleophilic heterocyclic amines (I) with a polymer-supported acylating agent or by reaction of amines with acyl halides in the presence of polymer-supported BEMP as base.

chemical structure image

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