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ChemInform Abstract: Synthesis and Antiviral Activity of 1,5- and 1,3-Dialkyl-1,2,4-triazole C-Nucleosides Derived from 1-(Chloroalkyl)-1-aza-2-azoniaallene Salts.
First published: 10 June 2010
Abstract
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ChemInform Abstract
Reaction of compounds (II) with SbCl5 gives the corresponding 1-aza-2-azoniaallene salts as reactive intermediates. Cycloaddition of these salts with the ribofuranosyl cyanide (I) affords after hydrolysis the triazole-C-nucleosides (III). The deprotected compounds do not display anti-HIV-activity.
