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ChemInform Abstract: Asymmetric Synthesis of 4′-Methyl-2′,3′-dideoxynucleosides.
First published: 10 June 2010
Abstract
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ChemInform Abstract
Asymmetric stereoselective preparation of a 4-methyl-2,3-dideoxyribose derivative is described which utilizes menthyl pyruvate as a chiral template and an organocerium addition as the key carbon—carbon bond-forming step. This compound (IX) is used as a substrate for a Vorbrueggen pyrimidine glycosylation giving an anomeric mixture of title compounds (X) and (XI).
