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ChemInform Abstract: Enantioselective Highly Efficient Synthesis of (-)-Cephalotaxine Using Two Palladium-Catalyzed Transformations.
First published: 10 June 2010
Abstract
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ChemInform Abstract
The highly efficient synthesis of title compound (I) involves enantioselective reduction of the brominated cyclopentenone derivative (II) for introduction of chirality and two successive Pd-catalyzed reactions as key reactions, i.e. allylation of sec. amine (V) with complete retention and diastereoselective Heck reaction of spirocyclic amine (VI).
