ChemInform Abstract: Synthesis and Structural Features of 11H-Tetrazolo[1,5-c][2,3]benzodiazepines.
Abstract
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ChemInform Abstract
The influence of the tetrazole nucleus in new tricyclic title compounds (II) on the conformational preferences of the seven-membered heterocyclic ring and on the anticonvulsant activity of their precursors, i.e. 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones, is investigated. It is found that the conformational mobility of the seven-membered ring is not effected as elucidated by dynamic NMR experiments and that there is no appreciable anticonvulsant activity as evaluated in a genetic model of epilepsy.The structures of these new compounds are determined by two-dimensional NMR techniques.
