Heterocyclic Compounds
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ChemInform Abstract: First Systematic Chiral Syntheses of Two Pairs of Enantiomers with 3,5-Dihydroxyheptenoic Acid Chain, Associated with a Potent Synthetic Statin NK-104.
First published: 10 June 2010
Abstract
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ChemInform Abstract
A pair of syn diol isomers like (IV) (precursor of NK-104) is obtained by diastereoselective reduction of (II) followed by diastereomeric resolution. The synthesis of a pair of anti diol isomers like (X) is accomplished effectively by the asymmetric aldol reaction followed by anti stereoselective reduction as key steps (no yields given).
