Volume 31, Issue 7
Heterocyclic Compounds
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ChemInform Abstract: Double Annulation Route to Fused Bicyclic Compounds with Three Contiguous Quaternary Centers.

Robert B. Grossman

Robert B. Grossman

Dep. Chem., Univ. Ky., Lexington, KY 40506, USA

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Aaron J. Skaggs

Aaron J. Skaggs

Dep. Chem., Univ. Ky., Lexington, KY 40506, USA

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Arlene E. Kray

Arlene E. Kray

Dep. Chem., Univ. Ky., Lexington, KY 40506, USA

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Brian O. Patrick

Brian O. Patrick

Dep. Chem., Univ. Ky., Lexington, KY 40506, USA

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First published: 10 June 2010

Abstract

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ChemInform Abstract

A stereoselective route towards bi- and tricyclic compounds featuring three new contiguous quaternary centers is discovered by reaction of a tethered bis(malononitrile) with alkynes. Two annulation modes are possible depending on the structure of the starting materials.

chemical structure image

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