ChemInform Abstract: Cerium(IV)-Catalyzed Deprotection of Acetals and Ketals under Mildly Basic Conditions.
Abstract
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ChemInform Abstract
Application of a novel highly efficient deprotection method with catalytic amounts of cerium ammonium nitrate under mildly basic conditions (borate—HCl buffer solution) to a series of acetals and ketals shows that the cerium catalyst is highly sensitive to steric hindrance in the ketal protecting group and/or in its immediate vicinity, e.g. prolonged reaction time required for deprotection of decalone derivative (VII) and total inertness of pinacol-derived ketal (IX) under these reaction conditions.
