Preparative Organic Chemistry
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ChemInform Abstract: Mixed Aggregates of Lithium Tetramethylpiperidide with Butyllithium: Stereoselectivity of Ketone Enolization.
First published: 19 June 2010
Abstract
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ChemInform Abstract
The enolization of 3-pentanone by lithium tetramethylpiperidide mixed aggregates with butyllithium is studied and the results are compared to those obtained using lithium tetramethylpiperidide alone. Mixed aggregates result in a slightly higher stereoselectivity which increases with decreasing percent conversion of the lithium base. The results are discussed based on ab initio and semiempirical calculations.
