Volume 29, Issue 31
Natural Products
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ChemInform Abstract: O-(Carboxydifluoromethyl)-L-tyrosine: Design and Synthesis of a Novel Non Phosphorous-Containing Phosphotyrosine Isostere.

H. FRETZ

H. FRETZ

Oncol. Res., Novartis Pharma Inc., CH-4002 Basel, Switz.

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First published: 20 June 2010

Abstract

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ChemInform Abstract

A synthesis leading to the racemic as well as to the L-configurated amino acid (IV), the title isostere, and its Fmoc-derivative is presented.

chemical structure image

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