ChemInform Abstract: Stereoselective Synthesis of (2S,3R)-N-Boc-3-hydroxyglutamic Acid.
Abstract
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ChemInform Abstract
An efficient route to the non-proteinogenic title amino acid (X) is developed. The route is based on a chelation-controlled diastereoselective addition of benzylmagnesium chloride (II) to the aldehyde derived from (I) providing the syn amino alcohol (III).