ChemInform Abstract: Synthesis of Tetrazole Analogues of α-Amino Acids by Alkylation of a Schiff Base of α-Aminomethyltetrazole.
Abstract
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ChemInform Abstract
The Schiff base (IV) undergoes efficient alkylation with organic halides to yield products (VI) as analogues of α-amino acids. In order to demonstrate their usefulness, a dipeptide C-terminal tetrazole (VIII) is prepared. Interestingly, the boron-containing alkylation product can be subjected to Suzuki—Miyaura reaction to yield para-substituted phenylalanine tetrazole derivatives (X).
