ChemInform Abstract: Synthesis of Constrained Bicyclic Dipeptide Mimetics.
Abstract
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ChemInform Abstract
As part of a program to develop low molecular weight thrombin inhibitors, the replacement of the dipeptide sequence (R)-Phe-Pro by mimetics is anticipated. Thus concise routes to (III), direct precursor of type (IV), and to the diastereomeric analogues (VI) and (VII) are developed.