Volume 29, Issue 1
Natural Products
Full Access

ChemInform Abstract: The Efficient Synthesis of a Bis-glycosylated Steroid Drug Transport Reagent: Methyl 3-β-Amino-7α-, 12α-Di(1′α-glucosyl)-5β-cholate (TC002).

M. J. SOFIA

M. J. SOFIA

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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R. KAKARLA

R. KAKARLA

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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N. KOGAN

N. KOGAN

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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R. DULINA

R. DULINA

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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Y. W. HUI

Y. W. HUI

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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N. T. HATZENBUHLER

N. T. HATZENBUHLER

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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D. LIU

D. LIU

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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A. CHEN

A. CHEN

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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T. WAGLER

T. WAGLER

Transcell Technol., Inc., Cranbury, NJ 08512, USA

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First published: 24 June 2010
Citations: 1

Abstract

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ChemInform Abstract

A large-scale synthesis of the facially amphiphilic drug transport reagent (VIII) is presented. Key step is the bis-glycosylation of (VII) with the anomeric sulfoxide (V).

chemical structure image

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