ChemInform Abstract: The Efficient Synthesis of a Bis-glycosylated Steroid Drug Transport Reagent: Methyl 3-β-Amino-7α-, 12α-Di(1′α-glucosyl)-5β-cholate (TC002).
Abstract
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ChemInform Abstract
A large-scale synthesis of the facially amphiphilic drug transport reagent (VIII) is presented. Key step is the bis-glycosylation of (VII) with the anomeric sulfoxide (V).