ChemInform Abstract: Two Useful Methods for the Preparation of (R)- and (S)-N-Methyl-1-phenyl-2-(1-pyrrolidinyl)ethanamine.
Abstract
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ChemInform Abstract
Title compound (IV), a useful reagent in organic synthesis and a precursor of analgesic compounds, is prepared in a two-step procedure from phenylglycinol. The second method is the previously reported one-pot procedure starting from enantiomerically pure styrene oxide. Both methods proceed via nucleophilic ring opening of an intermediate aziridinium ion and provide the shortest synthetic routes towards the title compounds.
