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ChemInform Abstract: Structure-Activity Relationships of 1β-Methyl-carbapenems to Antimicrobial Activity: Effect of C-6 Substituent.
First published: 02 August 2010
Abstract
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ChemInform Abstract
A study relating to the effect of the C-6 substituent in the title carbapenem is performed. Other side-chain variants are prepared in a similar fashion as derivative (IX). It is shown that the 6-(R) hydroxyethyl group is optimal for the desired biological activity ( some yields not given).
