Volume 28, Issue 50
Organoelement Compounds
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ChemInform Abstract: Synthesis and Evaluation of Benzophenone-Based Photoaffinity Labeling Analogues of Prenyl Pyrophosphates Containing Stable Amide Linkages.

T. C. TUREK

T. C. TUREK

Dep. Chem., Univ. Minn., Minneapolis, MN 55455, USA

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I. GAON

I. GAON

Dep. Chem., Univ. Minn., Minneapolis, MN 55455, USA

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D. GAMACHE

D. GAMACHE

Dep. Chem., Univ. Minn., Minneapolis, MN 55455, USA

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M. D. DISTEFANO

M. D. DISTEFANO

Dep. Chem., Univ. Minn., Minneapolis, MN 55455, USA

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First published: 02 August 2010

Abstract

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ChemInform Abstract

The synthesis of two photoreactive prenyl pyrophosphate analogues (VII) and (VIII), which prove to be competitive inhibitors of yeast farnesyl protein transferase with respect to farnesyl pyrophosphate is described.

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