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ChemInform Abstract: Total Synthesis of (+)-Aspicilin. The Naked Carbon Skeleton Strategy vs the Bioorganic Approach.
First published: 04 August 2010
Abstract
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ChemInform Abstract
The title compound (IX) is prepared from (I) with an overall yield of 11%. This approach is compared with an alternative and longer synthesis of (IX) with an overall yield of 4.3% using chiral building blocks derived from D-arabinose and from enzymatic reduction of oct-7- yn-2-one with Thermoanaerobium brockii alcoholdehydrogenase.
