Volume 28, Issue 15
Heterocyclic Compounds
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ChemInform Abstract: Synthesis of Novel Thiazolo(4,5-d)pyrimidine Derivatives for Antimicrobial, Anti-HIV and Anticancer Investigation.

S. M. RIDA

S. M. RIDA

Dep. Pharm. Chem., Fac. Sci., Univ. Alexandria, Alexandria, Egypt

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N. S. HABIB

N. S. HABIB

Dep. Pharm. Chem., Fac. Sci., Univ. Alexandria, Alexandria, Egypt

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E. A. M. BADAWEY

E. A. M. BADAWEY

Dep. Pharm. Chem., Fac. Sci., Univ. Alexandria, Alexandria, Egypt

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H. T. Y. FAHMY

H. T. Y. FAHMY

Dep. Pharm. Chem., Fac. Sci., Univ. Alexandria, Alexandria, Egypt

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H. A. GHOZLAN

H. A. GHOZLAN

Dep. Pharm. Chem., Fac. Sci., Univ. Alexandria, Alexandria, Egypt

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First published: 04 August 2010
Citations: 1

Abstract

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ChemInform Abstract

The title compounds (VIIa) and (VIIIa) show the highest antimicrobial activities. The introduction of dicyanomethylidene moiety to both thiazoles or thiazolo(4,5-d)pyrimidines enhances the antifungal activity. None of the tested compounds is sufficiently active for further investigations.

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