Volume 28, Issue 13
Natural Products
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ChemInform Abstract: Phosphono Analogues of Glutathione as New Inhibitors of Glutathione S- Transferases.

T. KUNZE

T. KUNZE

Pharm. Inst., Christian-Albrechts-Univ., D-24118 Kiel, Germany

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First published: 04 August 2010

Abstract

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ChemInform Abstract

Title analogues such as (I) are obtained by solution phase peptide synthesis. The most active one of this new class of inhibitors is compound (Id) with an IC50 of 21 μM against the human placental glutathione S-transferases.

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