ChemInform Abstract: Application of Chemical P-450 Model Systems to Studies on Drug Metabolism. Part 10. Novel Hydroxylactonization of γ,δ- and β,γ-Unsaturated Carboxylic Acids with an Iron Porphyrin- Iodosylbenzene System.
Abstract
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ChemInform Abstract
The title reaction is investigated with different kinds of unsaturated acids. The formation of hydroxy lactones is highly stereoselective. . beta.,γ-Unsaturated carboxylic acids are mainly decarboxylated. Lactone formation is observed in the case of iodomethacin, however with low yield and in a mixture of by-products. The lactones are also formed in the presence of microsomes. This metabolism is investigated and found to be cytochrome P-450 dependent.
