Volume 27, Issue 23
Natural Products
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ChemInform Abstract: Synthesis and Protein Tyrosine Phosphatase Inhibitory Activity of Dephostatin Analogues.

T. WATANABE

T. WATANABE

Dep. Appl. Chem., Fac. Sci. Technol., Kohoku, Yokohama 223, Japan

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T. TAKEUCHI

T. TAKEUCHI

Dep. Appl. Chem., Fac. Sci. Technol., Kohoku, Yokohama 223, Japan

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M. OTSUKA

M. OTSUKA

Dep. Appl. Chem., Fac. Sci. Technol., Kohoku, Yokohama 223, Japan

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S. TANAKA

S. TANAKA

Dep. Appl. Chem., Fac. Sci. Technol., Kohoku, Yokohama 223, Japan

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K. UMEZAWA

K. UMEZAWA

Dep. Appl. Chem., Fac. Sci. Technol., Kohoku, Yokohama 223, Japan

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First published: June 4, 1996

Abstract

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ChemInform Abstract

Among the dephostatin derivatives (13 examples) synthesized, only (Ib) shows PTPase inhibitory activity equivalent to that of dephostatin (Ia) , and also has increased stability.

chemical structure image

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