ChemInform Abstract: Pyridonecarboxylic Acids as Antibacterial Agents. Part 16. Imidazo- and Triazoloquinolones as Antibacterial Agents. Synthesis and Structure-Activity Relationships.
Abstract
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ChemInform Abstract
A series of substituted 6-cyclopropylimidazo- and triazoloquinoline-8- carboxylic acids (cf. (XIV) and (XII), resp.) are synthesized and evaluated for their in vitro antibacterial activity. Among the compounds synthesized, 5-fluoroimidazoquinolines of type (XIV) display potent and well-balanced antibacterial activity against both gram- positive and gram-negative bacteria. Structure-activity relationships are examined in detail.
