ChemInform Abstract: Synthesis of α-Trifluoromethyl Substituted α-Amino Acid Derivatives from Methyl 3,3,3-Trifluoro-2-diazopropionate.
Abstract
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ChemInform Abstract
Catalyzed decomposition of 3,3,3-trifluoro-2-diazopropionate (II) in the presence of the teriary amines (I) provides a new one-step procedure for the preparation of α-CF3-containing α-amino acids (III) via an (1,2)-Stevens rearrangement of the initially formed ylides. The ylides obtained from the interaction of (II) with the N-H nucleophiles (IV) form α-trifluoroalanines (V) via hydrogen migration.
