Heterocyclic Compounds
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ChemInform Abstract: Dibenzoxepinone Hydroxylamines and Hydroxamic Acids: Dual Inhibitors of Cyclooxygenase and 5-Lipoxygenase with Potent Topical Antiinflammatory Activity.
First published: April 30, 1996
Abstract
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ChemInform Abstract
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series are synthesized and the structure-activity relationship is investigated. On the basis of their promising profile of in vitro and in vivo activities the hydroxamic acids (III) and (V) are selected for toxicological assessment.
