Heterocyclic Compounds
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ChemInform Abstract: Preparation of Optically Active 8,8′-Disubstituted 1,1′-Biisoquinoline.
First published: April 30, 1996
Abstract
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ChemInform Abstract
A facile route to axially chiral biisoquinolines such as (VII) involving Ni(0)-mediated homocoupling of 1-chloroisoquinolines (cf. ( VI)) as the synthetic key step is described. The racemic product is resolved by HPLC on a chiral column on a preparative scale.
