Preparative Organic Chemistry
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ChemInform Abstract: Nitrilotriacetamide: Synthesis in Concentrated Sulfuric Acid and Stability in Water.
First published: April 16, 1996
Abstract
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ChemInform Abstract
Acid hydrolysis of nitilotriacetonitrile provides smoothly nitrolotriacetamide (II), which cyclizes to piperazineacetamide (III) on prolonged heating. Compound (II) slowly and cleanly converts to piperazineacetic acid (IV) in D2O.
