ChemInform Abstract: 1-(1-(4-((N-Acetyl-4-piperidinyl)oxy)-2-methoxybenzoyl)piperidin-4-yl)- 4H-3,1-benzoxazin-2(1H)-one (L-371,257): A New, Orally Bioavailable, Non-Peptide Oxytocin Antagonist.
Abstract
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ChemInform Abstract
In comparison with the uterine oxytocin receptor OPC 21268 (Xb) and similarly structured derivatives, compound (Xa) is found to be a more potent antagonist of oxytocin-induced contractions of rat uterus in vitro and in vivo having significant oral bioavailability in rats and suited as potential new therapeutic agent for treating preterm labor.