ChemInform Abstract: Synthetic Studies on Condensed-Azole Derivatives. Part 1. Synthesis and Anti-Asthmatic Activities of ω-Substituted Alkylthioimidazo( 1,2-b)pyridazines.
Abstract
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ChemInform Abstract
With a view to testing their interesting pharmacological properties different kinds of the title heterocycles such as (III)-(V), (VIII) and (X) are synthesized. None of the obtained compounds shows significant TXA2 inhibitory activity. Among a lot of synthesized derivatives of (X), compound (X) is the most potent anti-asthmatic derivative with effects superior to those of theophylline.