ChemInform Abstract: 4-(Heteroarylthio)-2-biphenylyltetrazoles as Nonpeptide Angiotensin II Antagonists.
Abstract
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ChemInform Abstract
A series of the title compounds (7 examples), such as (VIIa) and (VIIb) , are prepared and their ability to displace (3H)AII from angiotensin II receptors is investigated by comparing with already known antagonists (VIIIa) to (VIIIc). The most potent compounds (VIIa) and ( VIIb) exhibit also concentration-dependent reversal of angiotensin II contraction in rabbit isolated aortic rings. The effects of the novel sulfide bridging unit as well as changes in the heteroaromatic residue R on the biological activity are discussed.
