ChemInform Abstract: anti Aldol Reactions of Lactate-Derived Ketones: Application to the Total Synthesis of (-)-ACRL Toxin IIIB.
Abstract
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ChemInform Abstract
The boron-mediated anti aldol reaction of the (S)-ketone (I) is used twice in the 15-step synthesis of the fungal polyketide derivative (-)- ACRL toxin IIIA (VI), controlling the stereochemistry at C8/C9 and C12/ C13.