Volume 26, Issue 19
Natural Products
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ChemInform Abstract: Asymmetric Strecker Synthesis Using Enantiopure Sulfinimines: A Convenient Synthesis of α-Amino Acids.

F. A. DAVIS

F. A. DAVIS

Dep. Chem., Drexel Univ., Philadelphia, PA 19104, USA

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R. E. REDDY

R. E. REDDY

Dep. Chem., Drexel Univ., Philadelphia, PA 19104, USA

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P. S. PORTONOVO

P. S. PORTONOVO

Dep. Chem., Drexel Univ., Philadelphia, PA 19104, USA

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First published: May 9, 1995

Abstract

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ChemInform Abstract

The enantiopure sulfimines (I) react stereoselectively with diethylaluminum cyanide (II) to give the diastereomerically enriched . alpha.-amino nitriles (III) and (IV). After chromatographic separation the main isomers (III) are hydrolyzed to the desired α-amino acids.

chemical structure image

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