ChemInform Abstract: Asymmetric Strecker Synthesis Using Enantiopure Sulfinimines: A Convenient Synthesis of α-Amino Acids.
Abstract
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ChemInform Abstract
The enantiopure sulfimines (I) react stereoselectively with diethylaluminum cyanide (II) to give the diastereomerically enriched . alpha.-amino nitriles (III) and (IV). After chromatographic separation the main isomers (III) are hydrolyzed to the desired α-amino acids.