Volume 26, Issue 19
Heterocyclic Compounds
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ChemInform Abstract: Novel 5α-Reductase Inhibitors. Synthesis and Structure-Activity Studies of 5-Substituted 1-Methyl-2-pyridones and 1-Methyl-2- piperidones.

R. W. HARTMANN

R. W. HARTMANN

Fachrichtung 12. 1 Pharm. Chem., Univ. des Saarlandes, D-66041 Saarbruecken, Germany

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M. REICHERT

M. REICHERT

Fachrichtung 12. 1 Pharm. Chem., Univ. des Saarlandes, D-66041 Saarbruecken, Germany

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S. GOEHRING

S. GOEHRING

Fachrichtung 12. 1 Pharm. Chem., Univ. des Saarlandes, D-66041 Saarbruecken, Germany

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First published: May 9, 1995

Abstract

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ChemInform Abstract

Among several tested title compounds, the shown examples (III)-(VI) exhibit the best results in in vitro tests for the biological activity mentioned in the title. (III) are stronger inhibitors than (IV).

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