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ChemInform Abstract: The Chemistry of Pseudomonic Acid. Part 13. Modifications at C-12 to C- 14.
First published: February 28, 1995
Abstract
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ChemInform Abstract
The natural antibiotic pseudomonic acid A (XV) shows competitive inhibition activity against isoleucyl tRNA synthetase, whereby the C- 12 to C-14 moiety is essentially for the enzyme binding. The analogues (VI), (IX), (X), (XII), and (XIV) modified in this region are investigated with respect to antibacterial activity and enzyme binding properties.
