ChemInform Abstract: Synthesis and Glutamate Antagonist Activity of 4- Phosphonoalkylquinoline Derivatives: A Novel Class of Non-NMDA Antagonists.
Abstract
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ChemInform Abstract
Several title compounds, e.g. (IV), (V) and (X), demonstrate significant antagonism at 6-cyano-7-nitroquinoxalin-2,3-dione (CNQX) binding sites and the glycine regulatory site of the NMDA receptor.