ChemInform Abstract: New Asymmetric Synthesis of (-)-Esermethole.
Abstract
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ChemInform Abstract
(-)-Esermethole (-)-(XII) and (+)-esermethole are synthesized with a good degree of stereoselectivity (up to 63% d.e.) by use of the (S)- phenylethylamine (S)-(VIII) and its (R)-enantiomer as chiral alkylating agents, respectively. The use of (-)-menthyl chloroacetate as chiral aklylating agent under different reaction conditions (temp., solvent and base) only leads to moderate degrees of stereoselectivity ( 1-49% d.e.).
