Volume 25, Issue 35
Organoelement Compounds
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ChemInform Abstract: An Alternative Route to Aryloxymethylphosphonates and Phosphinates via Fluoride Ion Displacement from Activated Aromatic Substrates.

J. BERGE

J. BERGE

Dep. Med. Chem., SmithKline Beecham, Epsom, Surrey KT18 5XQ, UK

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G. N. MOORE

G. N. MOORE

Dep. Med. Chem., SmithKline Beecham, Epsom, Surrey KT18 5XQ, UK

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First published: August 30, 1994

Abstract

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ChemInform Abstract

In a one-pot procedure, the phosphonates and phosphinates (I) are transformed into the title aryloxymethylphosphonates and -phosphinates (IV) by hydroxymethylation and subsequent reaction with the activated fluoroarenes (III).

chemical structure image

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