Heterocyclic Compounds
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ChemInform Abstract: Preparation and Antitumor Activity of an N-Methylcarbamate Derivative of Amsacrine.
First published: March 29, 1994
Abstract
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ChemInform Abstract
The synthesis of the key intermediate (IV) in the preparation of the title compound (VIII) starts with the acid (I), which is obtained from commercially available 3-amino-4-methoxybenzoic acid. The cytotoxic activity of (VIII) against 4 human lung cancer cell lines reveals that it is as active as adriamycin and more cytotoxic than amsacrine.
