ChemInform Abstract: Reactions with 5-Trifluoromethyl-2,4-dihydropyrazol-3-one Derivatives: A New Route for the Synthesis of Fluorinated Polyfunctionally Substituted Pyrazole and Pyrano(2,3-c)pyrazole Derivatives.
Abstract
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ChemInform Abstract
In view of the fact that heterocyclic compounds containing a trifluoromethyl group are of interest due to their excellent pharmacological activity, the syntheses of a variety of title compounds are reported. The preparation of (V) is also achieved when using the corresponding ketoanilide instead of (IV). In contrast to the 5-methyl analogue, (Ia) and aromatic aldehydes such as (X) fail to give any characterizable products under the usual conditions. In an attempt to synthesize the 4-arylidene derivatives the reactions with the aldehyde are carried out under different conditions.
