Preparative Organic Chemistry
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ChemInform Abstract: One-Step Spiroannulation Using 1,2-Bis(methylene)cycloalkane-Magnesium Reagents.
First published: April 6, 1993
Abstract
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ChemInform Abstract
Treatment of the 1,2-bis(methylene)cycloalkanes (I) with activated magnesium generates a 1,2-bis(methylene)cyclohexane magnesium complex which is quenched with the α,ω-dihaloalkanes (II) to yield the spirocyclic compounds (III). Furthermore, quenching with the . omega.-bromo nitriles (IV) followed by hydrolytic work-up gives the spirocyclic ketones (V).
