ChemInform Abstract: Synthesis of Pyrrolidine Analogues of N-Acetylneuraminic Acid as Potential Sialidase Inhibitors.

ChemInform Abstract

The title compounds (+)-(XII), (+)-(XIV) and (+)-(XVI) (yield is not given) inhibit Vibrio cholerae sialidase. While (+)-(XII) and (+)-(XIV) are poor inhibitors, (+)-(XVI) is about equipotent with acetylneuramic acid. The synthesis is realized via the key intermediate (-)-(IX), whose structure is established in the form of its derivative (-)-(X) (space group P2₁2₁2₁ with Z = 8).