Volume 21, Issue 48
Heterocyclic Compounds
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ChemInform Abstract: Preparation of Triazolo(1,5-c)pyrimidines as Potential Antiasthma Agents.

J. B. MEDWID

J. B. MEDWID

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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R. PAUL

R. PAUL

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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J. S. BAKER

J. S. BAKER

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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J. A. BROCKMAN

J. A. BROCKMAN

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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M. T. DU

M. T. DU

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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W. A. HALLETT

W. A. HALLETT

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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J. W. HANIFIN

J. W. HANIFIN

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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R. A. JUN. HARDY

R. A. JUN. HARDY

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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M. E. TARRANT

M. E. TARRANT

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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L. W. TORLEY

L. W. TORLEY

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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S. WRENN

S. WRENN

Med. Res. Div., Lederle Lab., Am. Cyanamid Co., Pearl River, NY 10965, USA

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First published: November 27, 1990

ChemInform Abstract

The (het)aromatic nitriles (I) are converted into the 2-aryl-6-chloropyrimidines (VIII) which are transformed into the triazolopyrimidines (XII) via cyclization of the hydrazines (X) with cyanogen bromide (XI).

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