Heterocyclic Compounds
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ChemInform Abstract: Synthesis of Some 1,3,4-Oxa- and 1,3,4-Thiadiazole Derivatives.
First published: November 27, 1990
Abstract
Condensation of benzoyl chloride (I) with S-methyl hydrazinecarbodithioate (II) produces the benzoyl dithioate (III) which is cyclized to form the 1,3,4-thiadiazole (IV) or the 1,3,4-oxadiazole (V) upon reaction with phosphorus pentoxide or thionyl chloride respectively.
ChemInform Abstract
Condensation of benzoyl chloride (I) with S-methyl hydrazinecarbodithioate (II) produces the benzoyl dithioate (III) which is cyclized to form the 1,3,4-thiadiazole (IV) or the 1,3,4-oxadiazole (V) upon reaction with phosphorus pentoxide or thionyl chloride respectively. The 1,3,4-thiadiazoles (VII) and (X) as well as the 1,3,4-oxadiazoles (VIII) and (XI) are analogously prepared from terephthaloyl chloride (VI) and isoterephthaloyl chloride (IX).
