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ChemInform Abstract: Synthesis and Antimicrobial Properties of Substituted 3-Aminoxy-(E)-2-methoxyiminopropionyl Penicillins and Cephalosporins.
First published: September 11, 1990
Abstract
The title compounds of type (IV), (V) and (VI) are synthesized as described in the scheme.
ChemInform Abstract
The title compounds of type (IV), (V) and (VI) are synthesized as described in the scheme. Comparison of (IVa), (Va) and (VIa) with their analogues which lack the methoxyimino group shows that the antimicrobial activity of the former is generally lower. Only in the case of (IVa) higher activity toward Gram-positive resistant germs is observed. (IV) are also more active than penicillin G toward Gram-positive β-lactamase-producing germs.
