ChemInform Abstract: Fluorinated Acetylenes. Part 7. Preparation and Some Reactions of 4,4,4-Trifluorobut-2-ynoic Acid and 1-Phenyl-4,4,4-trifluorobut-2-yn-1-ol.
Abstract
Some reactions of the lithium salt (I) of 3,3,3-trifluoropropyne (prepared by bubbling the trifluoropropyne into a solution of n-butyllithium in hexane and dibutyl ether) with electrophiles such as the chloroformates (II), carbon dioxide (V), and benzaldehyde (VII) are reported.
ChemInform Abstract
Some reactions of the lithium salt (I) of 3,3,3-trifluoropropyne (prepared by bubbling the trifluoropropyne into a solution of n-butyllithium in hexane and dibutyl ether) with electrophiles such as the chloroformates (II), carbon dioxide (V), and benzaldehyde (VII) are reported. The expected products are obtained in moderate to good yields. 4,4,4-Trifluorobut-2-ynoic acid (VI) reacts with excess diazomethane (IX) to give the pyrazolines (XI) - (XIII) via the methyl ester (X).
