Volume 21, Issue 37
Isocyclic Compounds
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ChemInform Abstract: Facile Synthesis of β-Phenylethylamine Derivatives Related to Baclofen via Aziridine Ring Opening.

R. D. ALLAN

R. D. ALLAN

Dep. Pharmacol., Univ. Sydney, N. S. W. 2006

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H. W. TRAN

H. W. TRAN

Dep. Pharmacol., Univ. Sydney, N. S. W. 2006

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First published: September 11, 1990

Abstract

The aziridine derivative (I) is obtained from 4-chlorostyrene.

ChemInform Abstract

The aziridine derivative (I) is obtained from 4-chlorostyrene. After ring opening the thiols (III) or their analogues such as (VII) can be attached to give analogues such as (IV) of the GABAB receptor antagonist baclofen.

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