Preparative Organic Chemistry
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ChemInform Abstract: Superoxide Oxidation: A Novel Route to Aromatic 1,2-Dicarboxylic Acids.
First published: September 11, 1990
Abstract
Potassium superoxide and 18-crown-6 in an aprotic medium represent a reagent system for the mild oxidative cleavage of cyclic ketones fused to aromatic rings or phenols.
ChemInform Abstract
Potassium superoxide and 18-crown-6 in an aprotic medium represent a reagent system for the mild oxidative cleavage of cyclic ketones fused to aromatic rings or phenols. The corresponding dicarboxylic acids are obtained as the major products. E.g., the tetralones (I) and (IV) and α-naphthol (V) are converted to phthalic acid (II). Minor by-products are aromatic tetrones, e.g. (III). Further examples are given in the original paper.
