Preparative Organic Chemistry
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ChemInform Abstract: New Methodology for Conjugate Additions of Allylic Ligands to α,β-Unsaturated Ketones: Synthetic and Spectroscopic Studies.
First published: September 11, 1990
Abstract
Michael additions of allylic ligands to a variety of α,β-unsaturated ketones such as (I), (IV), or (VII) can be effected in synthetically useful yields with in situ generated allylcopper reagents such as (II), (V), (VIII) in the presence of trimethylchlorosilane.
ChemInform Abstract
Michael additions of allylic ligands to a variety of α,β-unsaturated ketones such as (I), (IV), or (VII) can be effected in synthetically useful yields with in situ generated allylcopper reagents such as (II), (V), (VIII) in the presence of trimethylchlorosilane. Low-temperature 13C NMR spectral studies suggest that the allylic ligands are σ-bound to copper.
