ChemInform Abstract: A Novel Heterocyclic Compound. Synthesis and Reactivities of an Oxazolo(3,2-a)thieno(3,2-d)pyrimidine Derivative.

ChemInform Abstract

Refluxing of the 3-aminothiophene (I) with 2-chloroethyl isocyanate (II) gives the urea (III). Cyclization of (III) upon treatment with NaOH forms the heterocyclic compound (IV) mentioned in the title. Two alternative multi-step syntheses of (IV) are given in the original paper. Reaction of (IV) with nucleophiles such as (V) results in opening of the oxazole ring to give the products (VI). Desulfurization of (IV) produces the oxazolopyrimidine derivative (VII). Compound (IV) shows potent antigastric secretion activity.