Heterocyclic Compounds
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ChemInform Abstract: New 7-Substituted Quinolone Antibacterial Agents. Part 2. The Synthesis of 1-Ethyl-1,4-dihydro-4-oxo-7-(pyrazolyl, isoxazolyl, and pyrimidinyl)-1,8-naphthyridine and -quinoline-3-carboxylic Acids.
First published: January 2, 1990
Abstract
A variety of title compounds such as (VII) are prepared as shown for (VIIa) via cyclization of a masked 1,3-dicarbonyl derivative such as (V).
ChemInform Abstract
A variety of title compounds such as (VII) are prepared as shown for (VIIa) via cyclization of a masked 1,3-dicarbonyl derivative such as (V). The pyrimidinyl analogues, substituted with a 2-amino or 2-aminomethyl group, are the only compounds with substantial antibacterial activity.
